Articles

Deangelis RA, Markiewski MM, Kourtzelis I, Rafail S, Syriga M, Sandor A, Maurya MR, Gupta S, Subramaniam S, Lambris JD. (2012). A Complement-IL-4 Regulatory Circuit Controls Liver Regeneration. Journal of immunology 188: 641-8.

Garcia BL, Summers BJ, Lin Z, Ramyar KX, Ricklin D, Kamath DV, Fu ZQ, Lambris JD, Geisbrecht BV. (2012). Diversity in the C3b Convertase Contact Residues and Tertiary Structures of the Staphylococcal Complement Inhibitor (SCIN) Protein Family. The Journal of Biological Chemistry 287: 628-40.

Sokolov A, Hellerud BC, Lambris JD, Johannessen EA, Mollnes TE. (2012). Activation of polymorphonuclear leukocytes by candidate biomaterials for an implantable glucose sensor. Journal of Diabetes Science and Technology 5: 1490-8.

Barratt-Due A, Thorgersen EB, Lindstad JK, Pharo A, Lissina O, Lambris JD, Nunn MA, Mollnes TE. (2011). Ornithodoros moubata Complement Inhibitor Is an Equally Effective C5 Inhibitor in Pigs and Humans. Journal of Immunology .

Bergseth G, Lambris JD, Mollnes TE, Lappeg�rd KT. (2011). Artificial surface-induced inflammation relies on complement factor 5: proof from a deficient person. The Annals of Thoracic Surgery 91: 527-33.

Brekke OL, Hellerud BC, Christiansen D, Fure H, Castellheim A, Nielsen EW, Pharo A, Lindstad JK, Bergseth G, Leslie G, Lambris JD, Brandtzaeg P, Mollnes TE. (2011). Neisseria meningitidis and Escherichia coli are protected from leukocyte phagocytosis by binding to erythrocyte complement receptor 1 in human blood. Molecular Immunology 48: 2159-69.

Carmona-Fontaine C, Theveneau E, Tzekou A, Tada M, Woods M, Page KM, Parsons M, Lambris JD, Mayor R. (2011). Complement Fragment C3a Controls Mutual Cell Attraction during Collective Cell Migration. Developmental Cell

Engberg AE, Rosengren-Holmberg JP, Chen H, Nilsson B, Lambris JD, Nicholls IA, Ekdahl KN. (2011). Blood protein-polymer adsorption: Implications for understanding complement-mediated hemoincompatibility. Journal of Biomedical Materials Research. Part A

Forneris F, Ricklin D, Wu J, Tzekou A, Wallace RS, Lambris JD, Gros P. (2011). Structures of C3b in complex with factors B and D give insight into complement convertase formation. Science 330: 1816-20. Additional Links: Supplementary Information.

Hajishengallis G, Liang S, Payne MA, Hashim A, Jotwani R, Eskan MA, McIntosh ML, Alsam A, Kirkwood KL, Lambris JD, Darveau RP, Curtis MA. (2011). Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and Complement. Cell Host & Microbe 10:1–10.

Hallstr�m T, Nordstr�m T, Tan TT, Manolov T, Lambris JD, Isenman DE, Zipfel PF, Blom AM, Riesbeck K. (2011). Immune Evasion of Moraxella catarrhalis Involves Ubiquitous Surface Protein A-Dependent C3d Binding. Journal of Immunology 186: 3120-9.

Ignatius A, Ehrnthaller C, Brenner RE, Kreja L, Schoengraf P, Lisson P, Blakytny R, Recknagel S, Claes L, Gebhard F, Lambris JD, Huber-Lang M. (2011). The Anaphylatoxin Receptor C5aR Is Present During Fracture Healing in Rats and Mediates Osteoblast Migration In Vitro. The Journal of Trauma 71(4):952-960 .

Ignatius A, Schoengraf P, Kreja L, Liedert A, Recknagel S, Kandert S, Brenner RE, Schneider M, Lambris JD, Huber-Lang M. (2011). Complement C3a and C5a modulate osteoclast formation and inflammatory response of osteoblasts in synergism with IL-1�. Journal of Cellular Biochemistry 112: 2594-605.

Kashem SW, Subramanian H, Collington SJ, Magotti P, Lambris JD, Ali H. (2011). G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: Roles of Mas-related genes MrgX1 and MrgX2. European Journal of Pharmacology 668: 299-304.

Knerr PJ, Tzekou A, Ricklin D, Qu H, Chen H, van der Donk WA, Lambris JD. (2011). Synthesis and activity of thioether-containing analogues of the complement inhibitor compstatin. ACS Chemical Biology 6: 753-60.

Liang S, Krauss JL, Domon H, McIntosh ML, Hosur KB, Qu H, Li F, Tzekou A, Lambris JD, Hajishengallis G. (2011). The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss. Journal of immunology 186: 869-77.

Moll G, Jitschin R, von Bahr L, Rasmusson-Duprez I, Sundberg B, L�nnies L, Elgue G, Nilsson-Ekdahl K, Mougiakakos D, Lambris JD, Ringd�n O, Le Blanc K, Nilsson B. (2011). Mesenchymal stromal cells engage complement and complement receptor bearing innate effector cells to modulate immune responses. PloS One 6: e21703.

Pavlov VI, Bonte LR, Baldwin WM, Markiewski M, Lambris J, Stahl GL. (2011). Absence of Mannose-Binding Lectin Prevents Hyperglycemic Cardiovascular Complications. The American Journal of Pathology 180:104-112.

Recknagel S, Bindl R, Kurz J, Wehner T, Schoengraf P, Ehrnthaller C, Qu H, Gebhard F, Huber-Lang M, Lambris JD, Claes L, Ignatius A. (2011). C5aR-antagonist significantly reduces the deleterious effect of a blunt chest trauma on fracture healing. Journal of Orthopaedic Research

Strey CW, Marquez-Pinilla RM, Markiewski MM, Siegmund B, Oppermann E, Lambris JD, Bechstein WO. (2011). Early post-operative measurement of cytokine plasma levels combined with pre-operative bilirubin levels identify high-risk patients after liver resection. International journal of molecular medicine 27: 447-54.

Subramanian H, Kashem SW, Collington SJ, Qu H, Lambris JD, Ali H. (2011). PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in human mast cells. Molecular Pharmacology 79: 1005-13.

Suetsugu-Maki R, Maki N, Fox TP, Nakamura K, Cowper Solari R, Tomlinson CR, Qu H, Lambris JD, Tsonis PA. (2011). A complement receptor C5a antagonist regulates epithelial to mesenchymal transition and crystallin expression after lens cataract surgery in mice. Molecular Vision 17: 949-64.

*Wu YQ, Qu H, Sfyroera G, Tzekou A, Kay BK, Nilsson B, Nilsson Ekdahl K, Ricklin D, Lambris JD.* (2011). Protection of nonself surfaces from complement attack by factor h-binding peptides: implications for therapeutic medicine. Journal of Immunology 186: 4269-77. * Shared Supervision . Additional Links: Podcast.

Amara U, Flierl MA, Rittirsch D, Klos A, Chen H, Acker B, Br�ckner UB, Nilsson B, Gebhard F, Lambris JD, Huber-Lang M. (2010). Molecular Intercommunication between the Complement and Coagulation Systems. Journal of Immunology 185: 5628-36.

Barratt-Due A, Thorgersen EB, Lindstad JK, Pharo A, Brekke OL, Christiansen D, Lambris JD, Mollnes TE. (2010). Selective inhibition of TNF-alpha or IL-1 beta does not affect E. coli-induced inflammation in human whole blood. Molecular immunology 47: 1774-82 .

Chen H, Ricklin D, Hammel M, Garcia BL, McWhorter WJ, Sfyroera G, Wu YQ, Tzekou A, Li S, Geisbrecht BV, Woods VL, Lambris JD. (2010). Allosteric inhibition of complement function by a staphylococcal immune evasion protein. Proceedings of the National Academy of Sciences of the United States of America 107: 17621-6:. Additional Links: Supplementary Information.

Danielsson A, Elgue G, Nilsson BM, Nilsson B, Lambris JD, T�tterman TH, Kochanek S, Kreppel F, Essand M. (2010). An ex vivo loop system models the toxicity and efficacy of PEGylated and unmodified adenovirus serotype 5 in whole human blood. Gene Therapy 17: 752-62.

Deak E, Jayakumar A, Cho KW, Goldsmith-Pestana K, Dondji B, Lambris JD, McMahon-Pratt D. (2010). Murine visceral leishmaniasis: IgM and polyclonal B-cell activation lead to disease exacerbation. European Journal of Immunology 40: 1355-68 .

Garcia BL, Ramyar KX, Tzekou A, Ricklin D, McWhorter WJ, Lambris JD, Geisbrecht BV. (2010). Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor (SCIN) bound to C3c and C3b. Journal of Molecular Biology 402: 17-29.

Grasis JA, Guimond DM, Cam NR, Herman K, Magotti P, Lambris JD, Tsoukas CD. (2010). In vivo significance of ITK-SLP-76 interaction in cytokine production. Molecular and cellular biology 30: 3596-609 .

Hamad OA, Nilsson PH, Lasaosa M, Ricklin D, Lambris JD, Nilsson B, Ekdahl KN. (2010). Contribution of chondroitin sulfate A to the binding of complement proteins to activated platelets. PloS one 5: e12889 .

Hamad OA, Nilsson PH, Wouters D, Lambris JD, Ekdahl KN, Nilsson B. (2010). Complement component C3 binds to activated normal platelets without preceding proteolytic activation and promotes binding to complement receptor 1. Journal of Immunology 184: 2686-92.

Haspel N, Geisbrecht BV, Lambris JD, Kavraki L. (2010). Multi-scale characterization of the energy landscape of proteins with application to the C3D/Efb-C complex. Proteins 78: 1004-14.

Kourtzelis I, Markiewski MM, Doumas M, Rafail S, Kambas K, Mitroulis I, Panagoutsos S, Passadakis P, Vargemezis V, Magotti P, Qu H, Mollnes TE, Ritis K, Lambris JD. (2010). Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis. Blood 116: 631-9.

*Langer HF, Chung KJ, Orlova VV, Choi EY, Kaul S, Kruhlak MJ, Alatsatianos M, Deangelis RA, Roche PA, Magotti P, Li X, Economopoulou M, Rafail S, Lambris JD, Chavakis T.* (2010). Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis. Blood 116: 4395-403 *Shared supervision.

Qu H, Magotti P, Ricklin D, Wu EL, Kourtzelis I, Wu YQ, Kaznessis YN, Lambris JD. (2010). Novel analogues of the therapeutic complement inhibitor compstatin with significantly improved affinity and potency. Molecular Immunology 48: 481-9.

*Silasi-Mansat R, Zhu H, Popescu NI, Peer G, Sfyroera G, Magotti P, Ivanciu L, Lupu C, Mollnes TE, Taylor FB, Kinasewitz G, Lambris JD, Lupu F.* (2010). Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis. Blood 116: 1002-10 *Shared Supervision .

Strey CW, Gestrich J, Beckhaus T, Marquez-Pinilla RM, Oppermann E, M�nch C, Lambris JD, Karas M, Bechstein WO. (2010). Hypoxia and reoxygenation of primary human hepatocytes induce proteome changes of glucose metabolism oxidative protection and peroxisomal function. International journal of molecular medicine 26: 577-84 .

Strey CW, Siegmund B, Rosenblum S, Marquez-Pinilla RM, Oppermann E, Huber-Lang M, Lambris JD, Bechstein WO. (2010). Complement and neutrophil function changes after liver resection in humans. World Journal of Surgery 33: 2635-43.

Wang M, Krauss JL, Domon H, Hosur KB, Liang S, Magotti P, Triantafilou M, Triantafilou K, Lambris JD, Hajishengallis G. (2010). Microbial hijacking of complement-toll-like receptor crosstalk. Science Signaling 16;3(109):ra11 . Additional Links: Podcast, Perspectives, Supplementary Information.

Garcia BL, Tzekou A, Ramyar KX, McWhorter WJ, Ricklin D, Lambris JD, Geisbrecht BV. (2009). Crystallization of human complement component C3b in the presence of a staphylococcal complement-inhibitor protein (SCIN). Acta crystallographica. Section F, Structural biology and crystallization communications 65: 482-5.

Georgopoulos LJ, Elgue G, Sanchez J, Dussupt V, Magotti P, Lambris JD, Tötterman TH, Maitland NJ, Nilsson B. (2009). Preclinical evaluation of innate immunity to baculovirus gene therapy vectors in whole human blood. Molecular immunology 46: 2911-7.

Lappeg�rd KK, Christiansen DD, Pharo AA, Thorgersen EE, Hellerud BB, Lindstad JJ, Nielsen EE, Bergseth GG, Fadnes DD, Abrahamsen TT, Høiby EE, Schejbel LL, Garred PP, Lambris JD, Harboe MM, Mollnes TT. (2009). Human genetic deficiencies reveal the roles of complement in the inflammatory network: lessons from nature. Proceedings of the National Academy of Sciences of the United States of America 106: 15861-6 .

Magotti P, Ricklin D, Qu H, Wu YQ, Kaznessis YN, Lambris JD. (2009). Structure-kinetic relationship analysis of the therapeutic complement inhibitor compstatin. Journal of Molecular Recognition 22: 495-505 .

Mangsbo SM, Sanchez J, Anger K, Lambris JD, Ekdahl KN, Loskog AS, Nilsson B, Totterman TH. (2009). Complement activation by CpG in a human whole blood loop system: mechanisms and immunomodulatory effects. J Immunol 183:6724-32. Additional Links: Supplementary Information.

Nakayama Y, Kim SI, Kim EH, Lambris JD, Sandor M, Suresh M. (2009). C3 promotes expansion of CD8+ and CD4+ T cells in a Listeria monocytogenes infection. Journal of Immunology 183: 2921-31 .

Ricklin D, Tzekou A, Garcia BL, Hammel M, McWhorter WJ, Sfyroera G, Wu YQ, Holers VM, Herbert AP, Barlow PN, Geisbrecht BV, Lambris JD. (2009). A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family. Journal of Immunology 183: 2565-74 .

Rooijakkers SH, Wu J, Ruyken M, van Domselaar R, Planken KL, Tzekou A, Ricklin D, Lambris JD, Janssen BJ, van Strijp JA, Gros P. (2009). Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor. Nature immunology 10: 721-7. Additional Links: Supplementary Information.

Thorgersen EB, Ludviksen JK, Lambris JD, Sfyroera G, Nielsen EW, Mollnes TE. (2009). Anti-inflammatory effects of c1-Inhibitor in porcine and human whole blood are independent of its protease inhibition activity. Innate Immunity : .

Wu J, Wu YQ, Ricklin D, Janssen BJ, Gros P, Lambris JD. (2009). Structure of complement fragment C3b-factor H and implications for host protection by complement regulators. Nature Immunology 10: 728-33. Additional Links: Supplementary Information.

Chen H, Schuster MC, Sfyroera G, Geisbrecht BV, Lambris JD. (2008). Solution insights into the structure of the Efb/C3 complement inhibitory complex as revealed by lysine acetylation and mass spectrometry. Journal of the American Society for Mass Spectrometry 19: 55-65.

Chiu TL, Mulakala C, Lambris JD, Kaznessis YN. (2008). Development of a new pharmacophore model that discriminates active compstatin analogs. Chemical Biology & Drug Design 72: 249-56 .

Fleming SD, Phillips LM, Lambris JD. (2008). Complement component C5a mediates hemorrhage-induced intestinal damage. J Surg Res 150:196-203.

Goto M, Tjernberg J, Dufrane D, Elgue G, Brandhorst D, Ekdahl KN, Brandhorst H, Wennberg L, Kurokawa Y, Satomi S, Lambris JD, Gianello P, Korsgren O, Nilsson B. (2008). Dissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation. Xenotransplantation 15: 225-34 .

Hadziahmetovic M, Dentchev T, Song Y, Haddad N, He XN, Hahn P, Pratico D, Wen R, Harris ZL, Lambris JD, Beard J, Dunaief JL. (2008). Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD. Investigative Ophthalmology & Visual Science 49 (6):2728-2736.

Hamad OA, Eldahi KN, Nilsson PH, Andersson J, Magotti P, Lambris JD, Nilsson B. (2008). Complement activation triggered by chondroitin sulfare released by thrombin receptoractivated platelets. Journal of Thromb Haemost 6 (8):1413-1421.

Haspel N, Ricklin D, Geisbrecht BV, Kavraki LE, Lambris JD. (2008). Electrostatic Contributions Drive the Interaction Between Staphylococcus aureus Protein Efb-C and its Complement Target C3d. Protein Science 17:1894-1906. Additional Links: Supplementary Material.

Hellerud BC, Stenvik J, Espevik T, Lambris JD, Mollnes TE, Brandtzaeg P. (2008). Stages of meningococcal sepsis simulated in vitro, with emphasis on complement and Toll-like receptor activation. Infection and Immunity 76: 4183-9 .

*Kambas K, Markiewski MM, Pneumatikos IA, Rafail S, Theodorou V, Konstantonis D, Kourtzelis I, Doumas MN, Magotti P, DeAngelis RA, Lambris JD, Ritis KD.* (2008). C5a and TNF-{alpha} up-regulate the expression of tissue factor in intra-alveolar neutrophils of patients with the acute respiratory distress syndrom. Journal of Immunology 180:7368-7375. *co-supervised this work.

Lappeg�rd KT, Bergseth G, Riesenfeld J, Pharo A, Magotti P, Lambris JD, Mollnes TE. (2008). The artificial surface-induced whole blood inflammatory reaction revealed by increases in a series of chemokines and growth factors is largely complement dependent. Journal of Biomedical Materials Research. Part A 87: 129-35 .

Markiewski MM, DeAngelis RA, Benencia F, Ricklin-Lichtsteiner SK, Koutoulaki A, Gerard C, Coukos G, Lambris JD. (2008). Modulation of the anti-tumor immune response by complement. Nature Immunology 9 (11):1225-1235. Additional Links: Nature Biotechnology News & Views, Nature Cancer Reviews Highlight, Nature Immunology News & Views, Supplementary Information.

Ricklin D, Ricklin-Lichtsteiner SK, Markiewski MM, Geisbrecht BV, Lambris JD. (2008). Cutting edge: members of the Staphylococcus aureus extracellular fibrinogen-binding protein family inhibit the interaction of C3d with complement receptor 2. Journal of Immunology 181: 7463-7 .

Rynkowski MA, Kim GH, Garrett MC, Zacharia BE, Otten ML, Sosunov SA, Komotar RJ, Hassid BG, Ducruet AF, Lambris JD, Connolly ES. (2008). C3a receptor antagonist attenuates brain injury after intracerebral hemorrhage. Journal of Cerebral Blood Flow and Metabolism 29: 98-107 .

Saethre M, Schneider MK, Lambris JD, Magotti P, Haraldsen G, Seebach JD, Mollnes TE. (2008). Cytokine secretion depends on Galalpha(1,3)Gal expression in a pig-to-human whole blood model. Journal of Immunology 180: 6346-53 .

Schuster MC, Ricklin D, Papp K, Molnar KS, Coales SJ, Hamuro Y, Sfyroera G, Chen H, Winters MS, Lambris JD. (2008). Dynamic structural changes during complement C3 activation analyzed by hydrogen/deuterium exchange mass spectrometry. Molecular Immunology 45: 3142-51 .

Tjernberg J, Ekdahl KN, Lambris JD, Korsgren O, Nilsson B. (2008). Acute antibody-mediated complement activation mediates lysis of pancreatic islets cells and may cause tissue loss in clinical islet transplantation. Transplantation 85: 1193-9 .

Zucchetti I, Marino R, Pinto MR, Lambris JD, Du Pasquier L, De Santis R. (2008). ciCD94-1, an ascidian multipurpose C-type lectin-like receptor expressed in Ciona intestinalis hemocytes and larval neural structures. Differentiation 76: 267-82 .

Hammel M, Sfyroera G, Pyrpassopoulos S, Ricklin D, Ramyar KX, Pop M, Jin Z, Lambris JD, Geisbrecht BV. (2007). Characterization of Ehp, a secreted complement inhibitory protein from Staphylococcus aureus. The Journal of Biological Chemistry 282: 30051-61 .

Hammel M, Sfyroera G, Ricklin D, Magotti P, Lambris JD, Geisbrecht BV. (2007). A structural basis for complement inhibition by Staphylococcus aureus. Nature Immunology 8: 430-7 . Additional Links: Science Editor's Choice.

Janssen BJ, Halff EF, Lambris JD, Gros P. (2007). Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition. The Journal of Biological Chemistry 282: 29241-7 . Additional Links: Supplementary Information.

J�zsi M, Oppermann M, Lambris JD, Zipfel PF. (2007). The C-terminus of complement factor H is essential for host cell protection. Molecular Immunology 44: 2697-706 .

Montalvo V, Campos MM, Chan CC, Wawrousek EF, Bush RA, Lambris JD, Gery I. (2007). Complement deposits on ocular tissues adjacent to sites of inflammation. Current Eye Research 32: 917-22 .

Mulakala C, Lambris JD, Kaznessis Y. (2007). A simple, yet highly accurate, QSAR model captures the complement inhibitory activity of compstatin. Bioorganic & Medicinal Chemistry 15: 1638-44 .

Pedersen ED, Aass HC, Rootwelt T, Fung M, Lambris JD, Mollnes TE. (2007). CD59 efficiently protects human NT2-N neurons against complement-mediated damage. Scandinavian Journal of Immunology 66: 345-51 .

Stevens B, Allen NJ, Vazquez LE, Howell GR, Christopherson KS, Nouri N, Micheva KD, Mehalow AK, Huberman AD, Stafford B, Sher A, Litke AM, Lambris JD, Smith SJ, John SW, Barres BA. (2007). The classical complement cascade mediates CNS synapse elimination. Cell 131: 1164-78 . Additional Links: Cell Preview, Science News of The Week.

Tamamis P, Skourtis SS, Morikis D, Lambris JD, Archontis G. (2007). Conformational analysis of compstatin analogues with molecular dynamics simulations in explicit water. Journal of Molecular Graphics & Modeling 26: 571-80 .

Thurman JM, Lenderink AM, Royer PA, Coleman KE, Zhou J, Lambris JD, Nemenoff RA, Quigg RJ, Holers VM. (2007). C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion. Journal of Immunology 178: 1819-28 .

Zhang X, Kimura Y, Fang C, Zhou L, Sfyroera G, Lambris JD, Wetsel RA, Miwa T, Song WC. (2007). Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo. Blood 110: 228-36 .

Anderson AL, Sporici R, Lambris J, Larosa D, Levinson AI. (2006). Pathogenesis of B-cell superantigen-induced immune complex-mediated inflammation. Infection and Immunity 74: 1196-203 .

Drouin SM, Sinha M, Sfyroera G, Lambris JD, Wetsel RA. (2006). A protective role for the fifth complement component (c5) in allergic airway disease. American Journal of Respiratory and Critical Care Medicine 173: 852-7 .

Huber-Lang M, Sarma JV, Zetoune FS, Rittirsch D, Neff TA, McGuire SR, Lambris JD, Warner RL, Flierl MA, Hoesel LM, Gebhard F, Younger JG, Drouin SM, Wetsel RA, Ward PA. (2006). Generation of C5a in the absence of C3: a new complement activation pathway. Nature Medicine 12: 682-7 .

Janssen BJ, Christodoulidou A, McCarthy A, Lambris JD, Gros P. (2006). Structure of C3b reveals conformational changes that underlie complement activity. Nature 444: 213-6 . Additional Links: News & Views.

Katragadda M, Lambris JD. (2006). Expression of compstatin in Escherichia coli: incorporation of unnatural amino acids enhances its activity. Protein Expression and Purification 47: 289-95 .

Katragadda M, Magotti P, Sfyroera G, Lambris JD. (2006). Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin. Journal of Medicinal Chemistry 49: 4616-22 .

K�hl J, Baelder R, Lewkowich IP, Pandey MK, Hawlisch H, Wang L, Best J, Herman NS, Sproles AA, Zwirner J, Whitsett JA, Gerard C, Sfyroera G, Lambris JD, Wills-Karp M. (2006). A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma. The Journal of Clinical Investigation 116: 783-96 .

Melillo D, Sfyroera G, De Santis R, Graziano R, Marino R, Lambris JD, Pinto MR. (2006). First identification of a chemotactic receptor in an invertebrate species: structural and functional characterization of Ciona intestinalis C3a receptor. Journal of immunology (Baltimore, Md. : 1950) 177: 4132-40 .

Miwa T, Zhou L, Tudoran R, Lambris JD, Madaio MP, Nangaku M, Molina H, Song WC. (2006). DAF/Crry double deficiency in mice exacerbates nephrotoxic serum-induced proteinuria despite markedly reduced systemic complement activity. Molecular Immunology 44: 139-46 .

Nielsen EW, Waage C, Fure H, Brekke OL, Sfyroera G, Lambris JD, Mollnes TE. (2006). Effect of supraphysiologic levels of C1-inhibitor on the classical, lectin and alternative pathways of complement. Molecular Immunology 44: 1819-26 .

Nozaki M, Raisler BJ, Sakurai E, Sarma JV, Barnum SR, Lambris JD, Chen Y, Zhang K, Ambati BK, Baffi JZ, Ambati J. (2006). Drusen complement components C3a and C5a promote choroidal neovascularization. Proceedings of the National Academy of Sciences of the United States of America 103: 2328-33 .

Ritis K, Doumas M, Mastellos D, Micheli A, Giaglis S, Magotti P, Rafail S, Kartalis G, Sideras P, Lambris JD. (2006). A novel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways. Journal of Immunology 177: 4794-802.

Soulika AM, Holland MC, Sfyroera G, Sahu A, Lambris JD. (2006). Compstatin inhibits complement activation by binding to the beta-chain of complement factor 3. Molecular Immunology 43: 2023-9 .

Bao L, Osawe I, Puri T, Lambris JD, Haas M, Quigg RJ. (2005). C5a promotes development of experimental lupus nephritis which can be blocked with a specific receptor antagonist. European Journal of Immunology 35: 2496-506 .

DeAngelis RA, Markiewski MM, Taub R, Lambris JD. (2005). A high-fat diet impairs liver regeneration in C57BL/6 mice through overexpression of the NF-kappaB inhibitor, IkappaBalpha. Hepatology 42: 1148-57 .

Lappeg�rd KT, Riesenfeld J, Brekke OL, Bergseth G, Lambris JD, Mollnes TE. (2005). Differential effect of heparin coating and complement inhibition on artificial surface-induced eicosanoid production. The Annals of Thoracic Surgery 79: 917-23 .

Li S, Boackle SA, Holers VM, Lambris JD, Blatteis CM. (2005). Complement component c5a is integral to the febrile response of mice to lipopolysaccharide. Neuroimmunomodulation 12: 67-80 .

Liu J, Miwa T, Hilliard B, Chen Y, Lambris JD, Wells AD, Song WC. (2005). The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo. The Journal of Experimental Medicine 201: 567-77 .

Mallik B, Katragadda M, Spruce LA, Carafides C, Tsokos CG, Morikis D, Lambris JD. (2005). Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. Journal of Medicinal Chemistry 48: 274-86 .

Pappas IS, Lambris JD, Vizirianakis IS, Winters MS, Tsiftsoglou AS. (2005). Mechanisms of action of differentiation inducers: detection of inducer binding protein(s) in murine erythroleukemia cells. Oncology Research 15: 21-37 .

Sfyroera G, Katragadda M, Morikis D, Isaacs SN, Lambris JD. (2005). Electrostatic modeling predicts the activities of orthopoxvirus complement control proteins. Journal of Immunology 174: 2143-51 .

Strey CW, Winters MS, Markiewski MM, Lambris JD. (2005). Partial hepatectomy induced liver proteome changes in mice. Proteomics 5: 318-25 .

Winters MS, Spellman DS, Lambris JD. (2005). Solvent accessibility of native and hydrolyzed human complement protein 3 analyzed by hydrogen/deuterium exchange and mass spectrometry. Journal of Immunology 174: 3469-74 .

Andersson J, Ekdahl KN, Lambris JD, Nilsson B. (2004). Binding of C3 fragments on top of adsorbed plasma proteins during complement activation on a model biomaterial surface. Biomaterials 26: 1477-85 .

Bell E, Shamim M, Whitbeck JC, Sfyroera G, Lambris JD, Isaacs SN. (2004). Antibodies against the extracellular enveloped virus B5R protein are mainly responsible for the EEV neutralizing capacity of vaccinia immune globulin. Virology 325: 425-31 .

Katragadda M, Morikis D, Lambris JD. (2004). Thermodynamic studies on the interaction of the third complement component and its inhibitor, compstatin. The Journal of Biological Chemistry 279: 54987-95 .

Kim AH, Dimitriou ID, Holland MC, Mastellos D, Mueller YM, Altman JD, Lambris JD, Katsikis PD. (2004). Complement C5a receptor is essential for the optimal generation of antiviral CD8+ T cell responses. Journal of Immunology 173: 2524-9 .

Klepeis JL, Floudas CA, Morikis D, Tsokos CG, Lambris JD. (2004). Design of peptide analogues with improves activity using a novel de Novo protein design approach. Industrial & Engineering Chemistry Research 43 (14):3817-3826 .

Lappeg�rd KT, Fung M, Bergseth G, Riesenfeld J, Lambris JD, Videm V, Mollnes TE. (2004). Effect of complement inhibition and heparin coating on artificial surface-induced leukocyte and platelet activation. The Annals of Thoracic Surgery 77: 932-41 .

Markiewski MM, Mastellos D, Tudoran R, DeAngelis RA, Strey CW, Franchini S, Wetsel RA, Erdei A, Lambris JD. (2004). C3a and C3b activation products of the third component of complement (C3) are critical for normal liver recovery after toxic injury. Journal of Immunology 173: 747-54 .

Mastellos D, Prechl J, L�szl� G, Papp K, Ol�h E, Argyropoulos E, Franchini S, Tudoran R, Markiewski M, Lambris JD Erdei A. (2004). Novel monoclonal antibodies against mouse C3 interfering with complement activation: description of fine specificity and applications to various immunoassays. Molecular Immunology 40: 1213-21 .

Morikis D, Lambris JD. (2004). The electrostatic nature of C3d-complement receptor 2 association. Journal of Immunology 172: 7537-47 .

Park JW, Taube C, Joetham A, Takeda K, Kodama T, Dakhama A, McConville G, Allen CB, Sfyroera G, Shultz LD, Lambris JD, Giclas PC, Holers VM, Gelfand EW. (2004). Complement activation is critical to airway hyperresponsiveness after acute ozone exposure. American Journal of Respiratory and Critical Care Medicine 169: 726-32 .

Sewell DL, Nacewicz B, Liu F, Macvilay S, Erdei A, Lambris JD, Sandor M, Fabry Z. (2004). Complement C3 and C5 play critical roles in traumatic brain cryoinjury: blocking effects on neutrophil extravasation by C5a receptor antagonist. Journal of Neuroimmunology 155: 55-63 .

Strey CW, Spellman D, Stieber A, Gonatas JO, Wang X, Lambris JD, Gonatas NK. (2004). Dysregulation of stathmin, a microtubule-destabilizing protein, and up-regulation of Hsp25, Hsp27, and the antioxidant peroxiredoxin 6 in a mouse model of familial amyotrophic lateral sclerosis. The American Journal of Pathology 165: 1701-18 .

Fleming SD, Mastellos D, Karpel-Massler G, Shea-Donohue T, Lambris JD, Tsokos GC. (2003). C5a causes limited, polymorphonuclear cell-independent, mesenteric ischemia/reperfusion-induced injury. Clinical Immunology 108: 263-73 .

Girardi G, Berman J, Redecha P, Spruce L, Thurman JM, Kraus D, Hollmann TJ, Casali P, Caroll MC, Wetsel RA, Lambris JD, Holers VM, Salmon JE. (2003). Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. The Journal of Clinical Investigation 112: 1644-54 . Additional Links: Erratum.

Holland MC, Lambris JD. (2003). A functional C5a anaphylatoxin receptor in a teleost species. Journal of Immunology 172: 349-55 .

Isaacs SN, Argyropoulos E, Sfyroera G, Mohammad S, Lambris JD. (2003). Restoration of complement-enhanced neutralization of vaccinia virus virions by novel monoclonal antibodies raised against the vaccinia virus complement control protein. Journal of Virology 77: 8256-62 .

Kazantzi A, Sfyroera G, Holland MC, Lambris JD, Zarkadis IK. (2003). Molecular cloning of the beta subunit of complement component eight of rainbow trout. Developmental and Comparative Immunology 27: 167-74 .

Kimura Y, Madhavan M, Call MK, Santiago W, Tsonis PA, Lambris JD, Del Rio-Tsonis K. (2003). Expression of complement 3 and complement 5 in newt limb and lens regeneration. Journal of Immunology 170: 2331-9 . Additional Links: In This Issue.

Klepeis JL, Floudas CA, Morikis D, Tsokos CG, Argyropoulos E, Spruce L, Lambris JD. (2003). Integrated computational and experimental approach for lead optimization and design of compstatin variants with improved activity. Journal of the American Chemical Society 125: 8422-3 . Additional Links: Supplementary Information.

Mallik B, Lambris JD, Morikis D. (2003). Conformational interconversion in compstatin probed with molecular dynamics simulations. Proteins 53: 130-41 .

Mullick J, Bernet J, Singh AK, Lambris JD, Sahu A. (2003). Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) open reading frame 4 protein (kaposica) is a functional homolog of complement control proteins. Journal of Virology 77: 3878-81 .

Pinto MR, Chinnici CM, Kimura Y, Melillo D, Marino R, Spruce LA, De Santis R, Parrinello N, Lambris JD. (2003). CiC3-1a-mediated chemotaxis in the deuterostome invertebrate Ciona intestinalis (Urochordata). Journal of Immunology 171: 5521-8 .

Reca R, Mastellos D, Majka M, Marquez L, Ratajczak J, Franchini S, Glodek A, Honczarenko M, Spruce LA, Janowska-Wieczorek A, Lambris JD, Ratajczak MZ. (2003). Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1. Blood 101: 3784-93 .

Soulika AM, Morikis D, Sarrias MR, Roy M, Spruce LA, Sahu A, Lambris JD. (2003). Studies of structure-activity relations of complement inhibitor compstatin. Journal of Immunology 171: 1881-90 .

Strey CW, Markiewski M, Mastellos D, Tudoran R, Spruce LA, Greenbaum LE, Lambris JD. (2003). The proinflammatory mediators C3a and C5a are essential for liver regeneration. The Journal of Experimental Medicine 198: 913-23 .

Suresh M, Molina H, Salvato MS, Mastellos D, Lambris JD, Sandor M. (2003). Complement component 3 is required for optimal expansion of CD8 T cells during a systemic viral infection. Journal of Immunology 170: 788-94 .

Barilla-LaBarca ML, Liszewski MK, Lambris JD, Hourcade D, Atkinson JP. (2002). Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells. Journal of Immunology 168: 6298-304 .

Huber-Lang MS, Riedeman NC, Sarma JV, Younkin EM, McGuire SR, Laudes IJ, Lu KT, Guo RF, Neff TA, Padgaonkar VA, Lambris JD, Spruce L, Mastellos D, Zetoune FS, Ward PA. (2002). Protection of innate immunity by C5aR antagonist in septic mice. The FASEB Journal 16: 1567-74 .

Laudes IJ, Chu JC, Huber-Lang M, Guo RF, Riedemann NC, Sarma JV, Mahdi F, Murphy HS, Speyer C, Lu KT, Lambris JD, Zetoune FS, Ward PA. (2002). Expression and function of C5a receptor in mouse microvascular endothelial cells. Journal of Immunology 169: 5962-70 .

Lubinski JM, Jiang M, Hook L, Chang Y, Sarver C, Mastellos D, Lambris JD, Cohen GH, Eisenberg RJ, Friedman HM. (2002). Herpes simplex virus type 1 evades the effects of antibody and complement in vivo. Journal of Virology 76: 9232-41 .

Marino R, Kimura Y, De Santis R, Lambris JD, Pinto MR. (2002). Complement in urochordates: cloning and characterization of two C3-like genes in the ascidian Ciona intestinalis. Immunogenetics 53: 1055-64 .

Molina H, Miwa T, Zhou L, Hilliard B, Mastellos D, Maldonado MA, Lambris JD, Song WC. (2002). Complement-mediated clearance of erythrocytes: mechanism and delineation of the regulatory roles of Crry and DAF. Decay-accelerating factor. Blood 100: 4544-9 .

Mollnes TE, Brekke OL, Fung M, Fure H, Christiansen D, Bergseth G, Videm V, Lappeg�rd KT, K�hl J, Lambris JD. (2002). Essential role of the C5a receptor in E coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation. Blood 100: 1869-77 .

Morikis D, Roy M, Sahu A, Troganis A, Jennings PA, Tsokos GC, Lambris JD. (2002). The structural basis of compstatin activity examined by structure-function-based design of peptide analogs and NMR. The Journal of Biological Chemistry 277: 14942-53 . Additional Links: Supplementary Information.

Riedemann NC, Guo RF, Neff TA, Laudes IJ, Keller KA, Sarma VJ, Markiewski MM, Mastellos D, Strey CW, Pierson CL, Lambris JD, Zetoune FS, Ward PA. (2002). Increased C5a receptor expression in sepsis. The Journal of Clinical Investigation 110: 101-8 .

Riedemann NC, Neff TA, Guo RF, Bernacki KD, Laudes IJ, Sarma JV, Lambris JD, Ward PA. (2002). Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression. Journal of Immunology 170: 503-7 .

Rux AH, Lou H, Lambris JD, Friedman HM, Eisenberg RJ, Cohen GH. (2002). Kinetic analysis of glycoprotein C of herpes simplex virus types 1 and 2 binding to heparin, heparan sulfate, and complement component C3b. Virology 294: 324-32 .

Sahu A, Morikis D, Lambris JD. (2002). Compstatin, a peptide inhibitor of complement, exhibits species-specific binding to complement component C3. Molecular Immunology 39: 557-66 .

S�lvik UO, Haraldsen G, Fiane AE, Boretti E, Lambris JD, Fung M, Thorsby E, Mollnes TE. (2002). Human serum-induced expression of E-selectin on porcine aortic endothelial cells in vitro is totally complement mediated. Transplantation 72: 1967-73 .

Wyss-Coray T, Yan F, Lin AH, Lambris JD, Alexander JJ, Quigg RJ, Masliah E. (2002). Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice. Proceedings of the National Academy of Sciences of the United States of America 99: 10837-42 .

Franchini S, Zarkadis IK, Sfyroera G, Sahu A, Moore WT, Mastellos D, LaPatra SE, Lambris JD. (2001). Cloning and purification of the rainbow trout fifth component of complement (C5). Developmental and Comparative Immunology 25: 419-30 .

Guthridge JM, Rakstang JK, Young KA, Hinshelwood J, Aslam M, Robertson A, Gipson MG, Sarrias MR, Moore WT, Meagher M, Karp D, Lambris JD, Perkins SJ, Holers VM. (2001). Structural studies in solution of the recombinant N-terminal pair of short consensus/complement repeat domains of complement receptor type 2 (CR2/CD21) and interactions with its ligand C3dg. Biochemistry 40: 5931-41 .

Guthridge JM, Young K, Gipson MG, Sarrias MR, Szakonyi G, Chen XS, Malaspina A, Donoghue E, James JA, Lambris JD, Moir SA, Perkins SJ, Holers VM. (2001). Epitope mapping using the X-ray crystallographic structure of complement receptor type 2 (CR2)/CD21: identification of a highly inhibitory monoclonal antibody that directly recognizes the CR2-C3d interface. Journal of Immunology 167: 5758-66 .

Mastellos D, Papadimitriou JC, Franchini S, Tsonis PA, Lambris JD. (2001). A novel role of complement: mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration. Journal of Immunology 166: 2479-86 .

Sarrias MR, Franchini S, Canziani G, Argyropoulos E, Moore WT, Sahu A, Lambris JD. (2001). Kinetic analysis of the interactions of complement receptor 2 (CR2, CD21) with its ligands C3d, iC3b, and the EBV glycoprotein gp350/220. Journal of Immunology 167: 1490-9 . Additional Links: Biacore PDF.

Sarrias MR, Whitbeck JC, Rooney I, Ware CF, Eisenberg RJ, Cohen GH, Lambris JD. (2001). The three HveA receptor ligands, gD, LT-alpha and LIGHT bind to distinct sites on HveA. Molecular Immunology 37: 665-73 .

Vasta GR, Lambris JD. (2001). Innate immunity in the Aegean: ancient pathways for today's survival. Developmental and Comparative Immunology 26: 217-25 .

Fiane AE, Videm V, Lambris JD, Geiran OR, Svennevig JL, Mollnes TE. (2000). Modulation of fluid-phase complement activation inhibits hyperacute rejection in a porcine-to-human xenograft model. Transplantation Proceedings 32: 899-900 .

Friedman HM, Wang L, Pangburn MK, Lambris JD, Lubinski J. (2000). Novel mechanism of antibody-independent complement neutralization of herpes simplex virus type 1. Journal of Immunology 165: 4528-36 .

Lubinski J, Wang L, Mastellos D, Sahu A, Lambris JD, Friedman HM. (2000). In vivo role of complement-interacting domains of herpes simplex virus type 1 glycoprotein gC. The Journal of Experimental Medicine 190: 1637-46 .

Sahu A, Soulika AM, Morikis D, Spruce L, Moore WT, Lambris JD. (2000). Binding kinetics, structure-activity relationship, and biotransformation of the complement inhibitor compstatin. Journal of Immunology 165: 2491-9 .

Soulika AM, Khan MM, Hattori T, Bowen FW, Richardson BA, Hack CE, Sahu A, Edmunds LH, Lambris JD. (2000). Inhibition of heparin/protamine complex-induced complement activation by Compstatin in baboons. Clinical Immunology 96: 212-21 .

Zarkadis IK, Sarrias MR, Sfyroera G, Sunyer JO, Lambris JD. (2000). Cloning and structure of three rainbow trout C3 molecules: a plausible explanation for their functional diversity. Developmental and Comparative Immunology 25: 11-24 .

Del Rio-Tsonis K, Tsonis PA, Zarkadis IK, Tsagas AG, Lambris JD. (1999). Expression of the third component of complement, C3, in regenerating limb blastema cells of urodeles. Journal of Immunology 161: 6819-24 .

Fiane AE, Mollnes TE, Videm V, Hovig T, H�g�sen K, Mellbye OJ, Spruce L, Moore WT, Sahu A, Lambris JD. (1999). Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts. Xenotransplantation 6: 52-65 .

Fiane AE, Mollnes TE, Videm V, Hovig T, H�g�sen K, Mellbye OJ, Spruce L, Moore WT, Sahu A, Lambris JD. (1999). Prolongation of ex vivo-perfused pig xenograft survival by the complement inhibitor Compstatin. Transplantation Proceedings 31: 934-5 .

Klepeis JL, Floudas CA, Morikis D, Lambris JD. (1999). Predicting peptide structures using NMR data and deterministic global optimization. Journal of Computational Chemistry 20:1354-1370 .

Lambris JD, Reid KB, Volanakis JE. (1999). The evolution, structure, biology and pathophysiology of complement. Immunology Today 20: 207-11 .

Noorchashm H, Moore DJ, Lieu YK, Noorchashm N, Schlachterman A, Song HK, Lambris JD, Barker CF, Naji A. (1999). Contribution of the innate immune system to autoimmune diabetes: A role for the CR1/CR2 complement receptors. Cellular Immunology 195:75-79 .

Sarrias MR, Whitbeck JC, Rooney I, Spruce L, Kay BK, Montgomery RI, Spear PG, Ware CF, Eisenberg RJ, Cohen GH, Lambris JD. (1999). Inhibition of herpes simplex virus gD and lymphotoxin-alpha binding to HveA by peptide antagonists. Journal of Virology 73: 5681-7 .

Sun X, Funk CD, Deng C, Sahu A, Lambris JD, Song WC. (1999). Role of decay-accelerating factor in regulating complement activation on the erythrocyte surface as revealed by gene targeting. Proceedings of the National Academy of Sciences of the United States of America 96: 628-33 .

Al-Sharif WZ, Sunyer JO, Lambris JD, Smith LC. (1998). Sea urchin coelomocytes specifically express a homologue of the complement component C3. Journal of Immunology 160: 2983-97 .

Krummenacher C, Nicola AV, Whitbeck JC, Lou H, Hou W, Lambris JD, Geraghty RJ, Spear PG, Cohen GH, Eisenberg RJ. (1998). Herpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpesvirus entry mediator, two structurally unrelated mediators of virus entry. Journal of Virology 72: 7064-74 .

Lubinski JM, Wang L, Soulika AM, Burger R, Wetsel RA, Colten H, Cohen GH, Eisenberg RJ, Lambris JD, Friedman HM. (1998). Herpes simplex virus type 1 glycoprotein gC mediates immune evasion in vivo. Journal of Virology 72: 8257-63 .

Morikis D, Assa-Munt N, Sahu A, Lambris JD. (1998). Solution structure of Compstatin, a potent complement inhibitor. Protein Science 7: 619-27 .

Nilsson B, Larsson R, Hong J, Elgue G, Ekdahl KN, Sahu A, Lambris JD. (1998). Compstatin inhibits complement and cellular activation in whole blood in two models of extracorporeal circulation. Blood 92: 1661-7 .

Peng T, Ponce de Leon M, Novotny MJ, Jiang H, Lambris JD, Dubin G, Spear PG, Cohen GH, Eisenberg RJ. (1998). Structural and antigenic analysis of a truncated form of the herpes simplex virus glycoprotein gH-gL complex. Journal of Virology 72: 6092-103 .

Sahu A, Isaacs SN, Soulika AM, Lambris JD. (1998). Interaction of vaccinia virus complement control protein with human complement proteins: factor I-mediated degradation of C3b to iC3b1 inactivates the alternative complement pathway. Journal of Immunology 160: 5596-604 .

Sunyer JO, Zarkadis I, Sarrias MR, Hansen JD, Lambris JD. (1998). Cloning, structure, and function of two rainbow trout Bf molecules. Journal of Immunology 161: 4106-14 .

Tolnay M, Lambris JD, Tsokos GC. (1998). Transcriptional regulation of the complement receptor 2 gene: role of a heterogeneous nuclear ribonucleoprotein. Journal of Immunology 159: 5492-501 .

Kostavasili I, Sahu A, Friedman HM, Eisenberg RJ, Cohen GH, Lambris JD. (1997). Mechanism of complement inactivation by glycoprotein C of herpes simplex virus. Journal of Immunology 158: 1763-71 .

Sunyer JO, Tort L, Lambris JD. (1997). Structural C3 diversity in fish: characterization of five forms of C3 in the diploid fish Sparus aurata. Journal of immunology 158: 2813-21 .

Sunyer JO, Tort L, Lambris JD. (1997). Diversity of the third form of complement, C3, in fish: functional characterization of five forms of C3 in the diploid fish Sparus aurata. The Biochemical Journal 326 ( Pt 3): 877-81 .

Whitbeck JC, Peng C, Lou H, Xu R, Willis SH, Ponce de Leon M, Peng T, Nicola AV, Montgomery RI, Warner MS, Soulika AM, Spruce LA, Moore WT, Lambris JD, Spear PG, Cohen GH, Eisenberg RJ. (1997). Glycoprotein D of herpes simplex virus (HSV) binds directly to HVEM, a member of the tumor necrosis factor receptor superfamily and a mediator of HSV entry. Journal of Virology 71: 6083-93 .

Zarkadis IK, Omigbodun A, Forson A, Ziolkiewicz P, Kinoshita T, Lambris JD, Coutifaris C. (1997). Differentiation-dependent changes in human trophoblast expression of decay-accelerating factor are modulated by 3',5' cyclic adenosine monophosphate. Journal of the Society for Gynecologic Investigation 4: 47-53 .

Friedman HM, Wang L, Fishman NO, Lambris JD, Eisenberg RJ, Cohen GH, Lubinski J. (1996). Immune evasion properties of herpes simplex virus type 1 glycoprotein gC. Journal of Virology 70: 4253-60 .

Kozlowski LM, Soulika AM, Silverman GJ, Lambris JD, Levinson AI. (1996). Complement activation by a B cell superantigen. Journal of Immunology 157: 1200-6 .

Lambris JD, Lao Z, Oglesby TJ, Atkinson JP, Hack CE, Becherer JD. (1996). Dissection of CR1, factor H, membrane cofactor protein, and factor B binding and functional sites in the third complement component. Journal of Immunology 156: 4821-32 .

Moore DJ, Lambris JD. (1996). Mass spectrometric analysis of the activation products of the thrid component of complement. Techniques in Protein Chemistry VII Academic Press 7:81-91 .

Rux AH, Moore WT, Lambris JD, Abrams WR, Peng C, Friedman HM, Cohen GH, Eisenberg RJ. (1996). Disulfide bond structure determination and biochemical analysis of glycoprotein C from herpes simplex virus. Journal of Virology 70: 5455-65 .

Sahu A, Kay BK, Lambris JD. (1996). Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library. Journal of Immunology 157: 884-91 .

Stavridi ES, O'Malley K, Lukacs CM, Moore WT, Lambris JD, Christianson DW, Rubin H, Cooperman BS. (1996). Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced sensitivity to proteolysis. Biochemistry 35: 10608-15 .

Sunyer JO, Zarkadis IK, Sahu A, Lambris JD. (1996). Multiple forms of complement C3 in trout that differ in binding to complement activators. Proceedings of the National Academy of Sciences of the United States of America 93: 8546-51 .

Kozlowski LM, Lambris JD, Levinson AI. (1995). Effect of a putative B cell superantigen on complement. Annals of the New York Academy of Sciences 764: 356-8 .

Lambris JD, Pappas J, Mavroidis M, Wang Y, Manzone H, Schwager J, Du Pasquier L, Silibovsky R, Swager J [corrected to Schwager J. (1995). The third component of Xenopus complement: cDNA cloning, structural and functional analysis, and evidence for an alternate C3 transcript. European Journal of Immunology 25: 572-8 .

Mavroidis M, Sunyer JO, Lambris JD. (1995). Isolation, primary structure, and evolution of the third component of chicken complement and evidence for a new member of the alpha 2-macroglobulin family. Journal of Immunology 154: 2164-74 .

Hasty LA, Brockman WW, Lambris JD, Lyttle CR. (1994). Hormonal regulation of complement factor B in human endometrium. American Journal of Reproductive Immunology 30: 63-7 .

Hasty LA, Lambris JD, Lessey BA, Pruksananonda K, Lyttle CR. (1994). Hormonal regulation of complement components and receptors throughout the menstrual cycle. American Journal of Obstetrics and Gynecology 170: 168-75 .

Hedrick JA, Lao Z, Lipps SG, Wang Y, Todd SC, Lambris JD, Tsoukas CD. (1994). Characterization of a 70-kDa, EBV gp350/220-binding protein on HSB-2 T cells. Journal of Immunology 153: 4418-26 .

Hung SL, Peng C, Kostavasili I, Friedman HM, Lambris JD, Eisenberg RJ, Cohen GH. (1994). The interaction of glycoprotein C of herpes simplex virus types 1 and 2 with the alternative complement pathway. Virology 203: 299-312 .

Lambris JD, Lao Z, Pang J, Alsenz J. (1994). Third component of trout complement. cDNA cloning and conservation of functional sites. Journal of Immunology 151: 6123-34 .

Lambris JD, Mavroidis M, Pappas J, Lao Z, Wang Y. (1994). Phylogeny of the third complement component, C3, and conservation of C3-ligand interactions. Annals of the New York Academy of Sciences 712: 354-7 .

Lao Z, Wang Y, Mavroidis M, Kostavasili I, Lambris JD. (1994). Overexpression, purification, and characterization of third component of complement. Journal of Immunological Methods 176: 127-39 .

Smith CI, Baskin B, Humire-Greiff P, Zhou JN, Olsson PG, Maniar HS, Kjell�n P, Lambris JD, Christensson B, Hammarstr�m L. (1994). Expression of Bruton's agammaglobulinemia tyrosine kinase gene, BTK, is selectively down-regulated in T lymphocytes and plasma cells. Journal of Immunology 152: 557-65 .

Sinha SK, Todd SC, Hedrick JA, Speiser CL, Lambris JD, Tsoukas CD. (1993). Characterization of the EBV/C3d receptor on the human Jurkat T cell line: evidence for a novel transcript. Journal of Immunology 150: 5311-20 .

Alsenz J, Avila D, Huemer HP, Esparza I, Becherer JD, Kinoshita T, Wang Y, Oppermann S, Lambris JD. (1992). Phylogeny of the third component of complement, C3: analysis of the conservation of human CR1, CR2, H, and B binding sites, concanavalin A binding sites, and thiolester bond in the C3 from different species. Developmental and Comparative Immunology 16: 63-76 .

Becherer JD, Alsenz J, Esparza I, Hack CE, Lambris JD. (1992). Segment spanning residues 727-768 of the complement C3 sequence contains a neoantigenic site and accommodates the binding of CR1, factor H, and factor B. Biochemistry 31: 1787-94 .

Hedrick JA, Watry D, Speiser C, O'Donnell P, Lambris JD, Tsoukas CD. (1992). Interaction between Epstein-Barr virus and a T cell line (HSB-2) via a receptor phenotypically distinct from complement receptor type 2. European Journal of Immunology 22: 1123-31 .

Kaufman J, Andersen R, Avila D, Engberg J, Lambris J, Salomonsen J, Welinder K, Skj�dt K. (1992). Different features of the MHC class I heterodimer have evolved at different rates. Chicken B-F and beta 2-microglobulin sequences reveal invariant surface residues. Journal of Immunology 148: 1532-46 .

Nilsson B, Grossberger D, Nilsson Ekdahl K, Riegert P, Becherer DJ, Nilsson UR, Lambris JD. (1992). Conformational differences between surface-bound and fluid-phase complement-component-C3 fragments. Epitope mapping by cDNA expression. The Biochemical Journal 282 ( Pt 3): 715-21 .

Esparza I, Becherer JD, Alsenz J, De la Hera A, Lao Z, Tsoukas CD, Lambris JD. (1991). Evidence for multiple sites of interaction in C3 for complement receptor type 2 (C3d/EBV receptor, CD21). European Journal of Immunology 21: 2829-38 .

M�ller LB, Kaufman J, Verland S, Salomonsen J, Avila D, Lambris JD, Skj�dt K. (1991). Variations in the cytoplasmic region account for the heterogeneity of the chicken MHC class I (B-F) molecules. Immunogenetics 34: 110-20 .

Watry D, Hedrick JA, Siervo S, Rhodes G, Lamberti JJ, Lambris JD, Tsoukas CD. (1991). Infection of human thymocytes by Epstein-Barr virus. The Journal of Experimental Medicine 173: 971-80 .

Avila D, Lambris JD. (1990). Isolation and characterization of the third complement component of axolotl (Ambystoma mexicanum). Comparative Biochemistry and Physiology. B, Comparative Biochemistry 95: 839-45 .

Nilsson B, Nilsson Ekdahl K, Avila D, Nilsson UR, Lambris JD. (1990). Neoantigens in complement component C3 as detected by monoclonal antibodies. Mapping of the recognized epitopes by synthetic peptides. The Biochemical Journal 268: 55-61 .

Tsokos GC, Lambris JD, Finkelman FD, Anastassiou ED, June CH. (1990). Monovalent ligands of complement receptor 2 inhibit whereas polyvalent ligands enhance anti-Ig-induced human B cell intracytoplasmic free calcium concentration. Journal of Immunology 144: 1640-5 .

Alsenz J, Lambris JD, Bork K, Loos M. (1989). Acquired C1 inhibitor (C1-INH) deficiency type II. Replacement therapy with C1-INH and analysis of patients' C1-INH and anti-C1-INH autoantibodies. The Journal of Clinical Investigation 83: 1794-9 .

Baxevanis CN, Reclos GJ, Servis C, Anastasopoulos E, Arsenis P, Katsiyiannis A, Matikas N, Lambris JD, Papamichail M. (1989). Peptides of myelin basic protein stimulate T lymphocytes from patients with multiple sclerosis. Journal of Neuroimmunology 22: 23-30 .

Bogen B, Lambris JD. (1989). Minimum length of an idiotypic peptide and a model for its binding to a major histocompatibility complex class II molecule. The EMBO Journal 8: 1947-52 .

Dihanich M, van Tuinen E, Lambris JD, Marshallsay B. (1989). Accumulation of viruslike particles in a yeast mutant lacking a mitochondrial pore protein. Molecular and Cellular Biology 9: 1100-8 .

Gisler RH, Schlienger C, S�derberg A, Ledermann F, Lambris JD. (1989). Functional maturation of murine B lymphocyte precursors--III. Soluble factors involved in the regulation of growth and differentiation. Molecular Immunology 25: 1113-27 .

Grossberger D, Marcuz A, Du Pasquier L, Lambris JD. (1989). Conservation of structural and functional domains in complement component C3 of Xenopus and mammals. Proceedings of the National Academy of Sciences of the United States of America 86: 1323-7 .

Huemer HP, Br�ker M, Larcher C, Lambris JD, Dierich MP. (1989). The central segment of herpes simplex virus type 1 glycoprotein C (gC) is not involved in C3b binding: demonstration by using monoclonal antibodies and recombinant gC expressed in Escherichia coli. The Journal of General Virology 70 ( Pt 6): 1571-8 .

Lassila O, Lambris JD, Gisler RH. (1989). A role for Lys-His-Gly-NH2 in avian and murine B cell development. Cellular Immunology 122: 319-28 .

Pluschke G, Bordmann G, Daoudaki ME, Lambris JD, Achtman M, Neibert M. (1989). Isolation of rat IgM to IgG hybridoma isotype switch variants and analysis of the efficiency of rat Ig in complement activation. European Journal of Immunology 19: 131-5 .

Servis C, Lambris JD. (1989). C3 synthetic peptides support growth of human CR2-positive lymphoblastoid B cells. Journal of Immunology 142: 2207-12 .

Becherer JD, Lambris JD. (1988). Identification of the C3b receptor-binding domain in third component of complement. The Journal of Biological Chemistry 263: 14586-91 .

Daoudaki ME, Becherer JD, Lambris JD. (1988). A 34-amino acid peptide of the third component of complement mediates properdin binding. Journal of Immunology 140: 1577-80 .

Frei Y, Lambris JD, Stockinger B. (1988). Generation of a monoclonal antibody to mouse C5 application in an ELISA assay for detection of anti-C5 antibodies. Molecular and Cellular Probes 1: 141-9 .

Lambris JD, Avila D, Becherer JD, M�ller-Eberhard HJ. (1988). A discontinuous factor H binding site in the third component of complement as delineated by synthetic peptides. The Journal of Biological Chemistry 263: 12147-50 .

Reclos JG, Baxevanis CN, Servis K, Arsenis P, Katsiyiannis A, Matikas N, Lambris JD, Papamichail M. (1988). Proliferative responces of T lymphocytes from patients with Multiple Sclerosis to human myelin basic protein peptides. In Trends in European Multiple Sclerosis research. Elsevier Science Pub 211-215 .

Tsoukas CD, Lambris JD. (1988). Expression of CR2/EBV receptors on human thymocytes detected by monoclonal antibodies. European Journal of Immunology 18: 1299-302 .

Tsokos GC, Inghirami G, Lambris JD. (1987). Regulation of human cytotoxic responses by complement: C3, C3b and C3d preparations enhance human allogeneic cytotoxic responses. Journal of Immunopharmacology 8: 529-41.

Alsenz J, Schulz TF, Lambris JD, Sim RB, Dierich MP. (1986). Structural and functional analysis of the complement component factor H with the use of different enzymes and monoclonal antibodies to factor H. The Biochemical Journal 232: 841-50 .

Hirani S, Lambris JD, M�ller-Eberhard HJ. (1986). Structural analysis of the asparagine-linked oligosaccharides of human complement component C3. The Biochemical Journal 233: 613-6 .

Inghirami G, Lambris JD, Tsokos GC. (1986). Complement receptors (CR) and cytotoxic responses: monoclonal antibodies directed against CR1 and CR3 inhibit the generation of human allospecific and virus specific cytotoxic cells in vitro. Journal of Immunopharmacology 8: 75-88 .

Tsonis PA, Lambris JD. (1986). Similarities between a conserved sequence element of homoeo boxes and other genes. FEBS letters 194: 263-6 .

Aguado MT, Lambris JD, Tsokos GC, Burger R, Bitter-Suermann D, Tamerius JD, Dixon FJ, Theofilopoulos AN. (1985). Monoclonal antibodies against complement 3 neoantigens for detection of immune complexes and complement activation. Relationship between immune complex levels, state of C3, and numbers of receptors for C3b. The Journal of Clinical Investigation 76: 1418-26 .

Alsenz J, Lambris JD, Schulz TF, Dierich MP. (1985). Localization of the complement component C3b binding site and the cofactor activity for factor I in the 38kDa tryptic fragment of factor H. The Biochemical Journal 224: 389-98 .

Hirani S, Lambris JD, M�ller-Eberhard HJ. (1985). Localization of the conglutinin binding site on the third component of human complement. Journal of Immunology 134: 1105-9 .

Lambris JD, Hirani S, Ganu VS, Becherer D, M�ller-Eberhard HJ. (1985). Synthetic peptides predicted from the nucleotide sequence of complement C3 bind to C3d receptor and monoclonal antibody 130. Advances in Gene Technology:Molecular Biology of the Immune System 2:213-214 .

Pryzwansky KB, Lambris JD, MacRae EK, Schwab JH. (1985). Opsonized streptococcal cell walls cross-link human leukocytes and erythrocytes by complement receptors. Infection and immunity 49: 550-6 .

Schulz TF, Scharfenberger H, Lambris JD, Rieber P, Riethm�ller G, Dierich MP. (1985). Antigenic relationship between the alpha-chain of C3, a leucocyte-surface antigen involved in the activation of phagocytic cells, and a 50,000 MW B-cell antigen. Immunology 54: 791-800 .

Tsokos GC, Inghirami G, Tsoukas CD, Balow JE, Lambris JD. (1985). Regulation of immunoglobulin secretion by factor H of human complement. Immunology 55: 419-26 .

Lambris JD, Alsenz J, Schulz TF, Dierich MP. (1984). Mapping of the properdin-binding site in the third component of complement. The Biochemical Journal 217: 323-6 .

Lambris JD, M�ller-Eberhard HJ. (1984). Isolation and characterization of a 33,000-dalton fragment of complement Factor B with catalytic and C3b binding activity. The Journal of Biological Chemistry 259: 12685-90 .

Lambris JD, Scheiner O, Schulz TF, Alsenz J, Dierich MP. (1984). Coupling of C3b to erythrocytes by disulfide bond formation: preparation of EC3b for hemolytic and complement receptor assays. Journal of Immunological Methods 65: 277-83 .

Schulz TF, Scheiner O, Alsenz J, Lambris JD, Dierich MP. (1984). Use of monoclonal antibodies against factor H to investigate the role of a membrane-associated protein antigenically related to H in C3b-receptor function. Journal of Immunology 132: 392-8 .

Tsoukas CD, Lambris J, Lotz M, Valentine MA, Vaughan JH, Carson DA. (1984). Lymphocyte mitogenesis induced by monoclonal antibodies to the T3 complex. Differential modulation by human IgG. Cellular Immunology 89: 66-74 .

Hutt-Fletcher LM, Fowler E, Lambris JD, Feighny RJ, Simmons JG, Ross GD. (1983). Studies of the Epstein Barr virus receptor found on Raji cells. II. A comparison of lymphocyte binding sites for Epstein Barr virus and C3d. Journal of Immunology 130: 1309-12 .

Pryzwansky KB, MacRae EK, Lambris JD. (1983). Capping of complement receptors on human neutrophils induced by group A streptococcal cell walls. Journal of Immunology 130: 1674-7 .

Ross GD, Newman SL, Lambris JD, Devery-Pocius JE, Cain JA, Lachmann PJ. (1983). Generation of three different fragments of bound C3 with purified factor I or serum. II. Location of binding sites in the C3 fragments for factors B and H, complement receptors, and bovine conglutinin. The Journal of Experimental Medicine 158: 334-52 .

Scheiner O, Schulz TF, Schmid HU, Lambris JD, Alsenz J, Dierich MP. (1983). Importance of factors H and I for the adherence of C3b-coated erythrocytes to cells. Immunobiology 165: 211-24 .

Tsiganos CP, Stamatiadou M, Lambris J, Papamichail M. (1983). Detection of cartilage proteoglycan-related antigens on the surface of 3T3 cells. Progress in Clinical and Biological Research 102 pt A: 447-54 .

Lambris J, Papamichail M, Ioannidis C, Dimitracopoulos G. (1982). Activation of the alternative pathway of human complement by the extracellular slime glycolipoprotein of Pseudomonas aeruginosa. The Journal of Infectious Diseases 145: 78-82 .

Lambris JD, Allen JB, Schwab JH. (1982). In vivo changes in complement induced with peptidoglycan-polysaccharide polymers from streptococcal cell walls. Infection and Immunity 35: 377-80 .

Lambris JD, Ross GD. (1982). Assay of membrane complement receptors (CR1 and CR2) with C3b- and C3d-coated fluorescent microspheres. Journal of Immunology 128: 186-9 .

Lambris JD, Ross GD. (1982). Characterization of the lymphocyte membrane receptor for factor H (beta 1H-globulin) with an antibody to anti-factor H idiotype. The Journal of Experimental Medicine 155: 1400-11 .

Ross GD, Lambris JD. (1982). Identification of a C3bi-specific membrane complement receptor that is expressed on lymphocytes, monocytes, neutrophils, and erythrocytes. The Journal of Experimental Medicine 155: 96-110 .

Ross GD, Lambris JD, Cain JA, Newman SL. (1982). Generation of three different fragments of bound C3 with purified factor I or serum. I. Requirements for factor H vs CR1 cofactor activity. Journal of Immunology 129: 2051-60 .

Dobson NJ, Lambris JD, Ross GD. (1981). Characteristics of isolated erythrocyte complement receptor type one (CR1, C4b-C3b receptor) and CR1-specific antibodies. Journal of Immunology 126: 693-8 .

Lambris JD, Dobson NJ, Ross GD. (1981). Isolation of lymphocyte membrane complement receptor type two (the C3d receptor) and preparation of receptor-specific antibody. Proceedings of the National Academy of Sciences of the United States of America 78: 1828-32 .

Lambris JD, Dobson NJ, Ross GD. (1981). Release of endogenous C3b inactivator from lymphocytes in response to triggering membrane receptors for beta 1H globulin. The Journal of Experimental Medicine 152: 1625-44 .

Lambris J, Papamichail M. (1980). A method for analysing lymphocyte surface antigens. Journal of Immunological Methods 34: 287-93 .

Lambris J, Papavassiliou J, Dimitracopoulos G. (1980). Protein component of Pseudomonas aeruginosa slime glycolipoprotein in relation to laboratory-induced resistance to gentamicin. Canadian Journal of Microbiology 26:852-853 .

Lambris J, Papamichail M, Fessas P. (1979). Fluorescent labelling of proteins of lymphocyte plasma membranes. Journal of Immunological Methods 27: 55-9 .