The versatile functions of the human complement system in health and disease are largely based on a fascinating interaction network, which not only defines the activation and regulation of the cascade itself but also enables communication with other pathways. The Lambris Lab therefore initiated the "Complement Network Map" project, which visualizes interactions of complement proteins and their fragments with ligands from within the cascade, endogenous structures, and foreign cells such as microorganisms. The map is entirely based on published research data on direct molecular interactions and has been carefully verified by experts in the field. Each connection shown in the fully searchable map is hyperlinked and contains information about the publication sources and the analytical methods used for describing the interaction. As complement research has developed into a highly dynamic field, the map will be constantly extended and updated based on new information. The evidence-based foundation of the map renders in into a very reliable source for getting to know the complement system, discovering surprising connections, and generating novel research hypotheses. We look forward to see the map develop and hope that it will serve you as a guide on a fascinating journey through the complement field.

 

Contents:

 

   Complement Network Maps    

   Crosstalk with Other Pathways