Reviews & Chapters

Christiansen D, Brekke OL, Stenvik J, Lambris JD, Espevik T, Mollnes TE. (2011). Differential Effect of Inhibiting MD-2 and CD14 on LPS- Versus Whole E. coli Bacteria-Induced Cytokine Responses in Human Blood. Advances in Experimental Medicine and Biology 946: 237-51.
Ekdahl KN, Lambris JD, Elwing H, Ricklin D, Nilsson PH, Teramura Y, Nicholls IA, Nilsson B. (2011). Innate immunity activation on biomaterial surfaces: A mechanistic model and coping strategies. Advanced Drug Delivery Reviews 63: 1042-50.
Garcia BL, Ramyar KX, Ricklin D, Lambris JD, Geisbrecht BV. (2011). Advances in Understanding the Structure, Function, and Mechanism of the SCIN and Efb Families of Staphylococcal Immune Evasion Proteins.. Advances in Experimental Medicine and Biology 946: 113-33.
Hajishengallis G, Krauss JL, Liang S, McIntosh ML, Lambris JD. (2011). Pathogenic microbes and community service through manipulation of innate immunity. Advances in Experimental Medicine and Biology 946: 69-85.
Hajishengallis G, Lambris JD. (2011). Microbial manipulation of receptor crosstalk in innate immunity. Nature Reviews Immunology 11: 187-200. Additional Links: At a glance, Supplementary info.
Oikonomopoulou K, Ricklin D, Ward PA, Lambris JD. (2011). Interactions between coagulation and complement-their role in inflammation.. Seminars in immunopathology 34: 151-65.
Chi ZL, Yoshida T, Lambris JD, Iwata T. (2010). Suppression of Drusen Formation by Compstatin, a Peptide Inhibitor of Complement C3 activation, on Cynomolgus Monkey with Early-Onset Macular Degeneration. Advances in Experimental Medicine and Biology 703: 127-35.
Hajishengallis G, Lambris JD. (2010). Crosstalk pathways between Toll-like receptors and the complement system. Trends in Immunology 31: 154-63.
Hajishengallis G, Lambris JD. (2010). Illuminating the latest advances in innate immunity on the island of the sun god. Expert Review of Clinical Immunology 6: 875-8 .
Nilsson B, Korsgren O, Lambris JD, Ekdahl KN. (2010). Can cells and biomaterials in therapeutic medicine be shielded from innate immune recognition?. Trends in Immunology 31: 32-8.
Ricklin D, Hajishengallis G, Yang K, Lambris JD. (2010). Complement: a key system for immune surveillance and homeostasis. Nature Immunology 11: 785-97 .
Krauss JL, Potempa J, Lambris JD, Hajishengallis G. (2009). Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host. Periodontology 2000 52: 141-62.
Markiewski MM, DeAngelis RA, Lambris JD. (2009). Complexity of complement activation in sepsis. Journal of Cellular and Molecular Medicine 12: 2245-54.
Markiewski MM, Lambris JD. (2009). Unwelcome Complement. Cancer Research 69: 6367-70.
Markiewski MM, Lambris JD. (2009). Is complement good or bad for cancer patients? A new perspective on an old dilemma. Trends in Immunology 30: 286-92.
Qu H, Ricklin D, Lambris JD. (2009). Recent developments in low molecular weight complement inhibitors.. Molecular Immunology 47: 185-95.
Amara U, Rittirsch D, Flierl M, Bruckner U, Klos A, Gebhard F, Lambris JD, Huber-Lang M. (2008). Interaction between the coagulation and complement system. Advances in Experimental Medicine and Biology 632: 71-9.
Lambris JD, Ricklin D, Geisbrecht BV. (2008). Complement evasion by human pathogens. Nature reviews Microbiology 6: 132-42.
Ricklin D, Lambris JD. (2008). Compstatin: a complement inhibitor on its way to clinical application. Advances in Experimental Medicine and Biology 632: 273-92.
Markiewski MM, Lambris JD. (2007). The role of complement in inflammatory diseases from behind the scenes into the spotlight. American Journal of Pathology 171:715-727 .
Markiewski MM, Nilsson B, Ekdahl KN, Mollnes TE, Lambris JD. (2007). Complement and coagulation: strangers or partners in crime?. Trends in Immunology 28:184-192 .
Nilsson B, Ekdahl KN, Mollnes TE, Lambris JD. (2007). The role of complement in biomaterial-induced inflammation. Molecular Immunology 44 :82-94 .
Pinto MR, Melillo D, Giacomelli S, Sfyroera G, Lambris JD. (2007). Ancient origin of the complement system: Emerging invertebrate models. Adv Exp Med Biol 598:372-388 .
Ricklin D, Lambris JD. (2007). Exploring the complement interaction network using surface plasmon resonance. Adv Exp Med Biol 598:260-278 .
Ricklin D, Lambris JD. (2007). Complement-targeted therapeutics. Nature Biotechnology 25: 1265-75.
Schuster MC, Chen H, and Lambris JD. (2007). Hydrogen/Deuterium exchange mass spectrometry: Potential for investigating innate immunity proteins. Adv Exp Med Biol 598:407-417 .
Smith RJ, Alexander J, Barlow PN, Botto M, Cassavant TL, Cook HT, de Córdoba SR, Hageman GS, Jokiranta TS, Kimberling WJ, Lambris JD, Lanning LD, Levidiotis V, Licht C, Lutz HU, Meri S, Pickering MC, Quigg RJ, Rops AL, Salant DJ, Sethi S, Thurman JM, Tully HF, Tully SP, van der Vlag J, Walker PD, Würzner R, Zipfel PF. (2007). New Approaches to the Treatment of Dense Deposit Disease. Journal of the American Society of Nephrology 18:2447-2456 .
DeAngelis RA, Markiewski MM, Lambris JD. (2006). Liver regeneration: a link to inflammation through complement.. Advances in Experimental Medicine and Biology 586: 17-34 .
Mastellos D, Lambris JD. (2006). Cross-disciplinary research stirs new challenges into the study of the structure, function and systems biology of complement. Advances in Experimental Medicine and Biology 586: 1-16 .
Reca R, Wysoczynski M, Yan J, Lambris JD, Ratajczak MZ. (2006). The role of third complement component (C3) in homing of hematopoietic stem/progenitor cells into bone marrow. Advances in experimental medicine and biology 586: 35-51 .
Tsonis PA, Lambris JD, Del Rio-Tsonis K. (2006). To regeneration...with complement.. Advances in Experimental Medicine and Biology 586: 63-70 .
Morikis, D., Floudas, C. A., and Lambris, J. D. (2005). Structure-based integrative computational and experimental approach for the optimization of drug design. Computational Science - Iccs 2005, Pt 2 3515:680-688.
Appel GB, Cook HT, Hageman G, Jennette JC, Kashgarian M, Kirschfink M, Lambris JD, Lanning L, Lutz HU, Meri S, Rose NR, Salant DJ, Sethi S, Smith RJ, Smoyer W, Tully HF, Tully SP, Walker P, Welsh M, Würzner R, Zipfel PF. (2005). Membranoproliferative glomerulonephritis type II (dense deposit disease): an update.. Journal of the American Society of Nephrology 16: 1392-403 .
Markiewski MM, DeAngelis RA, Lambris JD. (2005). Liver inflammation and regeneration: two distinct biological phenomena or parallel pathophysiologic processes?. Molecular Immunology 43: 45-56 .
Mastellos D, Andronis C, Persidis A, Lambris JD. (2005). Novel biological networks modulated by complement. Clinical Immunology 115: 225-35 .
Mastellos D, Germenis AE, Lambris JD. (2005). Complement: an inflammatory pathway fulfilling multiple roles at the interface of innate immunity and development.. Current drug targets. Inflammation and allergy 4: 125-7 .
Mastellos D, Lambris JD. (2005). Intergrating Innate Immunity into a Global 'Systems' Context: the Complement Paradigm Shift. Systems Biology   .
Morikis D, Lambris JD. (2005). The building blocks of the complement system. The Structural Biology of The Complement System pp:1-18 .
Morikis D, Lambris JD. (2005). Structure, dynamics activity and function of compstatin and design of more potent analogs. The Structural Biology of the Complement System pp:317-340 .
Morikis,D. and Lambris,J.D. (2005). Structure of anaphylatoxins C3a and C5a. The structural Biology of the Complement System pp:161-178.
Floudas C A, Klepeis JL, Lambris JD, Morikis D. (2004). De Novo Protein Design" An Interplay of Global Optimization, Mixed-Integer Optimization and Experiments. Proceedings of FOCAPD pp:133-146 .
Holland MC, Morikis D, Lambris JD. (2004). Synthetic small-molecule complement inhibitors.. Current Opinion in Investigational Drugs 5: 1164-73 .
Holland MCH, Lambris JD. (2004). Complement. Nature Encyclopedia of Life Sciences   .
Mastellos D, Morikis D, Strey C, Holland MC, Lambris JD. (2004). From atoms to systems: a cross-disciplinary approach to complement-mediated functions. Molecular Immunology 41: 153-64 .
Morikis D, Lambris JD. (2004). Physical methods for structure, dynamics and binding in immunological research. Trends in Immunology 25: 700-7 .
Morikis D, Soulika AM, Mallik B, Klepeis JL, Floudas CA, Lambris JD. (2004). Improvement of the anti-C3 activity of compstatin using rational and combinatorial approaches. Biochemical Society Transactions 32: 28-32 .
Sarrias MR, Sahu A, Lambris JD. (2004). Characterization of the interactions of complement receptor 2 with its ligands iC3b,C3d and EBV glycoprotein gp350/220. Biacore Journal 4:14-17 .
Mastellos D, Morikis D, Isaacs SN, Holland MC, Strey CW, Lambris JD. (2003). Complement: structure, functions, evolution, and viral molecular mimicry.. Immunologic Research 27: 367-86 .
Morikis, D. and Lambris, J. D. (2002). Structural aspects and design of low-molecular-mass complement inhibitors. Biochemical Society Transactions 30:1026-1036.
Holland MC, Lambris JD. (2002). The complement system in teleosts. Fish & Shellfish Immunology 12: 399-420 .
Mastellos D, Lambris JD. (2002). Complement: more than a 'guard' against invading pathogens?. Trends in Immunology 23: 485-91 .
Mollnes TE, Song WC, Lambris JD. (2002). Complement in inflammatory tissue damage and disease. Trends in Immunology 23: 61-4 .
Sahu, A. and Lambris, J. D. (2002). Novel anti-factor D monoclonal antibody inhibits complement and leukocyte activation in a baboon model of cardiopulmonary bypass - Invited commentary. Annals of Thoracic Surgery 74 (2):362. Additional Links: Invited Commentary to Articles by Undar et al.
Sahu A, Lambris JD. (2001). Structure and biology of complement protein C3, a connecting link between innate and acquired immunity. Immunological Reviews 180: 35-48 .
Zarkadis IK, Mastellos D, Lambris JD. (2001). Phylogenetic aspects of the complement system. Developmental and Comparative Immunology 25: 745-62 .
Sahu A, Lambris JD. (2000). Complement inhibitors: a resurgent concept in anti-inflammatory therapeutics. Immunopharmacology 49: 133-48 .
Sahu A, Morikis D, Lambris JD. (2000). Complement inhibitor targeting C3,C4, and C5. Therapeutic interventions in the complement system 4:75-112 .
Song WC, Sarrias MR, Lambris JD. (2000). Complement and innate immunity. Immunopharmacology 49: 187-98 .
Lambris JD, Reid KB, Volanakis JE. (1999). The evolution, structure, biology and pathophysiology of complement.. Immunology Today 20: 207-11 .
Morikis D, Sahu A, Moore WT, Lambris JD. (1999). Design, structure, function and application of compstatin in Bioactive peptides in Drug discovery and design:medical aspects. IOS Press pp:235-246 .
Sunyer JO, Lambris JD. (1999). Evolution and diversity of the complement system of poikilothermic vertebrates.. Immunological Reviews 166: 39-57 .
Sunyer,J.O. and Lambris,J.D. (1999). Complement. Encyclopedia of Life Sciences
Lambris,J.D., Sahu,A., Wetsel,R.A. (1998). C3, C4 and C5:Genes, structure, and functions. The Human Complement System in Health and Disease pp:83-118.
Sahu A, Sunyer JO, Moore WT, Sarrias MR, Soulika AM, Lambris JD. (1998). Structure, functions, and evolution of the third complement component and viral molecular mimicry. Immunologic Research 17: 109-21 .
Sunyer JO, Zarkadis IK, Lambris JD. (1998). Complement diversity: a mechanism for generating immune diversity?. Immunology Today 19: 519-23 .
Lambris,J.D., Mavroidis,M. and Sunyer,J.O. (1994). Phylogeny of third component of complement, C3. New Aspects of complement structure and function 2:15-34.
Lambris, J. D. (1993). Chemistry, biology and phylogeny of C3. Complement Profiles 1:16-45.
Lambris JD, Becherer JD, Servis C, Alsenz J. (1993). Use of synthetic peptides in exploring and modifying complement reactivities. Activators and inhibitors of complement activation, Kluwer Academic Press, Lancaster pp:201-232 .
Tsoukas CD, Lambris JD. (1993). Expression of EBV/C3d receptors on T cells: biological significance.. Immunology Today 14: 56-9 .
Alsenz J, Becherer JD, Nilsson B, Lambris JD. (1990). Structural and functional analysis of C3 using monoclonal antibodies.. Current Topics in Microbiology and Immunology 153: 235-48 .
Becherer JD, Alsenz J, Lambris JD. (1990). Molecular aspects of C3 interactions and structural/functional analysis of C3 from different species.. Current Topics in Microbiology and Immunology 153: 45-72 .
Becherer JD, Alsenz J, Servis C, Myones BL, Lambris JD. (1989). Cell surface proteins reacting with activated complement components.. Complement and Inflammation 6: 142-65 .
Lambris JD. (1989). The multifunctional role of C3, the third component of complement.. Immunology Today 9: 387-93 .
Lambris JD, Müller-Eberhard HJ. (1987). The multifunctional role of C3: structural analysis of its interactions with physiological ligands.. Molecular Immunology 23: 1237-42 .
Lambris JD, Tsokos GC. (1986). The biology and pathophysiology of complement receptors.. Anticancer Research 6: 515-23 .

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